Power

flutiform offers sustained anti-inflammatory power1

Fluticasone propionate is a potent corticosteroid with sustained anti-inflammatory activity.1–3 It binds to glucocorticoid receptors within cells and decreases the release of inflammatory mediators from immune cells.4

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flutiform helps reduce asthma exacerbations5

Pooled analysis from 5 double-blind studies (8–12 weeks; flutiform 50/5, 125/5 and 250/10 μg vs. FP 50, 125 and 250 μg 2 puffs b.i.d).5 FP: fluticasone propionate; b.i.d: twice daily.

flutiform significantly reduces asthma exacerbations* vs. fluticasone propionate.In addition, two open-label, long-term studies showed that only 2.1% of patients taking flutiform experienced an exacerbation requiring oral corticosteroids.6

*Exacerbation defined as peak expiratory flow rate >30% below baseline ≥2 consecutive days, awakening at night due to asthma ≥2 consecutive days, rescue medication use at least 4–5 times/day ≥2 consecutive days, deterioration in asthma necessitating additional therapy, or emergency visit/hospitalisation due to asthma.

n=752 patients, Study 1: 60 weeks, Study 2: up to 52 weeks duration. Pooled analysis.

 

 

 

 

1. flutiform Summary of Product Characteristics 2015. 2. Mager DE et al. Pharm Sci. 2003; 92: 1521–1525. 3. Johnson M. J Allergy Clin Immunol. 1998; 101(4): S434S439. 4. Barnes PJ. British Journal of Pharmacology. 2006; 148(3): 245–254. 5. Papi A et al. Respir Med. 2015; 109(2): 208–217. 6. Papi A et al. J Aerosol Med Pulm Drug Deliv. 2016: 29; 346-361.

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